Study of Time-dependent Interaction of ZnO Nanoparticles with Sucrose and Honey Molecules for Biomedical Applications

Author(s): Pijus Kanti Samanta*, Tapanendu Kamilya, Dhrubajyoti Pahari.

Journal Name: Current Nanomaterials

Volume 4 , Issue 3 , 2019

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Abstract:

Background: Nanoparticles are in the forefront of research due to their unique properties that find possible applications from optoelectronics to medical technology. It is also reported that nanoparticles can interact with the living cells and can selectively destroy the cells. Researchers are thus interested to find a way by which the drugs will be attached to the nanoparticles, go to the target site and destroy the infected cells. Before that, it is very much important to understand the interaction of nanoparticles with the blood, plasma and other biological cells that exists in the blood. It is also very essential to understand how the nanoparticles interact with the absorbed sucrose in the cell.

Objective: Our objective in this research is to investigate the interaction of ZnO nanoparticles with sucrose and honey sugar to understand the basic interaction mechanism. It will also enable us to find a way of stabilizing body sucrose and glucose level.

Methods: We have followed a simple chemical synthesis method to prepare ultrafine ZnO nanoparticles. Then the interaction of ZnO nanoparticles with sucrose and honey sugar was investigated as a function of time using UV-visible spectroscopy to understand the basic interaction mechanism.

Results: Well grown ZnO nanoparticles were found to form of crystallite size ~38 nm. The band gap was calculated from the absorption spectra and was found to be ~ 3.9 eV. This band gap enhancement indicates that the sizes of the nanoparticles are very small. The decrease of absorption with time indicates that the ZnO nanoparticles interact with the sugar molecule. Sucrose molecules are polar. Hence there is electrostatic attraction between the sucrose molecules and ZnO molecules resulting in the sucrose-ZnO composite system. On increasing the interaction time more and more sucrose molecules will cover the ZnO nanoparticles by forming ZnO-sucrose corona. The interaction time constant i.e., the binding time of sucrose molecule with the surface of ZnO nanoparticles, t1 was found to be 27.7127 min and is 29.59 min for honey. The results indicate an association process to form corona of ZnO nanoparticles with sucrose and honey molecules.

Conclusion: We have successfully synthesized ultrafine ZnO nanoparticles of high band gap. The synthesized nanoparticles interact with the sucrose and honey molecules and form corona. This study is very important in understanding the interaction mechanism on nanoparticles with the biomolecules for possible drug delivery applications.

Keywords: ZnO, nanoparticles, sucrose, absorption, corona, conjugation.

[1]
Hassan HS, Elkady MF, Hafez EE, Salama E. Novel antibacterial zinc oxide polymeric nanocomposite membrane as wound dress. Nanosci Nanotechnol Asia 2017; 7: 62-72.
[http://dx.doi.org/10.2174/2210681206666160609083249]
[2]
Rani S, Lal B, Saxena S, Shukla S. Modifications in the structural and optical properties of ZnO nanophosphor on doping with tb. Nanosci Nanotechnol Asia 2018; 8: 1.
[3]
Samanta PK, Kamilya T, Bhunia AK. Structural and optical properties of ultra-long zno nanorods. Adv Sci Eng Med 2016; 8: 128-30.
[http://dx.doi.org/10.1166/asem.2016.1833]
[4]
He HY. Microstructural, optical and electrical properties of ZnO: pr thin films: pr-doping level effect. Micro Nanosyst 2016; 8: 19-25.
[http://dx.doi.org/10.2174/1876402908666160819145942]
[5]
Samanta PK, Basak S. Electrochemical growth of hexagonal ZnO pyramids and their optical property. Mater Lett 2012; 83: 97-9.
[http://dx.doi.org/10.1016/j.matlet.2012.05.133]
[6]
Samanta PK, Das M, Hati R, Patra M. Synthesis and optical absorption properties of copper oxide nanoparticles for applications in transparent surface coatings and solar cells. J Nano-Electron Phys 2017; 9(6): 06028-1-06028.
[7]
Rizvi SAA, Saleh AM. Applications of nanoparticle systems in drug delivery technology. Saudi Pharm J 2018; 26(1): 64-70.
[http://dx.doi.org/10.1016/j.jsps.2017.10.012] [PMID: 29379334]
[8]
Dreaden EC, El-Sayed MA. Detecting and destroying cancer cells in more than one way with noble metals and different confinement properties on the nanoscale Acc Chem Res 2012; 20; 45(11): 1854-65.
[http://dx.doi.org/10.1021/ar2003122]
[9]
Xu Z, Zhang Y, Wang Z. ZnO-based photodetector: from photon detector to pyro-phototronic effect enhanced detector. J Phys D Appl Phys 2019; 52(22)223001
[http://dx.doi.org/10.1088/1361-6463/ab0728]
[10]
Liu K, Sakurai M, Aono M. ZnO-based ultraviolet photodetectors. Sensors 2010; 10(9): 8604-34.
[http://dx.doi.org/10.3390/s100908604] [PMID: 22163675]
[11]
Hou Y, Jayatissa AH. Influence of laser doping on nanocrystalline ZnO thin films gas sensors. Prog Nat Sci-Mater 2017; 27: 435-42.
[http://dx.doi.org/10.1016/j.pnsc.2017.07.002]
[12]
Chackrabarti S, Hafiz AK, Zargar RA. A Comprehensive review of properties of screen-printed pure and doped ZnO and CdO thick films. Curr Altern Energy 2018; 2: 42-71.
[http://dx.doi.org/10.2174/2405463102666180704111918]
[13]
Samanta PK, Saha A, Kamilya T. Structural and optical property of spherical ZnO nanoparticles. Optik 2015; 126(18): 1740-3.
[http://dx.doi.org/10.1016/j.ijleo.2015.04.025]
[14]
Al-Salman HS, Abdullah MJ. Fabrication and characterization of ZnO thin film for hydrogen gas sensing prepared by RF-magnetron sputtering. Measurement 2013; 46: 1698-03.
[http://dx.doi.org/10.1016/j.measurement.2013.01.004]
[15]
Basak S, Samanta PK. Enhanced Photoluminescence from core-shell ZnO/ZnS nanostructures. J Chemical Eng Mater Sci 2012; 3(2): 18-22.
[16]
Peng-Shou X, Yu-Ming S, Chao-Shu S, Fa-Qiang X, Hai-Bin P. native point defect states in ZnO. Chin Phys Lett 2001; 18: 1252.
[http://dx.doi.org/10.1088/0256-307X/18/9/331]
[17]
Cao Y, Li J, Liu F, et al. Consideration of interaction between nanoparticles and food components for the safety assessment of nanoparticles following oral exposure: a review. Environ Toxicol Pharmacol 2016; 46: 206-10.
[http://dx.doi.org/10.1016/j.etap.2016.07.023] [PMID: 27497726]
[18]
Ahn CH, Kim YY, Kim DC, Mohanta SK, Cho HK. A com-parative analysis of deep level emission in ZnO layers deposited by various methods. J Appl Phys 2009; 105(1)013502
[http://dx.doi.org/10.1063/1.3054175]
[19]
Go MR, Yu J, Bae SH, Kim HJ, Choi SJ. Effects of interactions between ZnO nanoparticles and saccharides on biological responses. Int J Mol Sci 2018; 19(2)E486
[http://dx.doi.org/10.3390/ijms19020486] [PMID: 29415484]
[20]
Wu JZ, Williams GR, Li HY, et al. Glucose and temperature-sensitive nanoparticles for insulin delivery. Int J Nanomedicine 2017; 12: 4037-57.
[http://dx.doi.org/10.2147/IJN.S132984] [PMID: 28603417]
[21]
Cash KJ, Clark HA. Nanosensors and nanomaterials for monitoring glucose in diabetes. Trends Mol Med 2010; 16(12): 584-93.
[http://dx.doi.org/10.1016/j.molmed.2010.08.002] [PMID: 20869318]
[22]
Meulenkamp EA. Synthesis and growth of ZnO nanoparticles. J Phys Chem B 1998; 102: 5566-72.
[http://dx.doi.org/10.1021/jp980730h]
[23]
Samanta PK, Saha A, Kamilya T. Morphological and optical property of spherical ZnO nanoparticles. Optik 2015; 126(18): 1740-74.
[http://dx.doi.org/10.1016/j.ijleo.2015.04.025]
[24]
Samanta PK, Saha A, Kamilya T. Wet chemically synthesized CuO bipods and their optical properties. Recent Pat Nanotechnol 2016; 10(1): 20-5.
[http://dx.doi.org/10.2174/1872210510999160208155658] [PMID: 27018270]
[25]
Volden S, Kjaniksen AL, Zhu K, Genzer J, Nystroym B, Bloom WR. ZnO nanoparticle-protein interaction: corona formation with associated unfolding. ACS Nano 2010; 4: 1187.
[http://dx.doi.org/10.1021/nn901517u] [PMID: 20078133]
[26]
Bhunia AK, Samanta PK, Saha S, Kamilya T. Safety concerns towards the biomedical application of PbS nanoparticles: An approach through protein-PbS interaction and corona formation. Appl Phys Lett 2014.104123703
[http://dx.doi.org/10.1063/1.4869122]
[27]
Bhunia AK, Samanta PK, Saha S, Kamilya T. ZnO Nanoparticles- protein interaction: crona formation with associated unfolding. Appl Phys Lett 2013; 103(14): 14370.
[http://dx.doi.org/10.1063/1.4824021]
[28]
Samanta PK, Bhunia AK, Saha S, Kamilya T. Interaction of glucose with ZnO nanoparticles. J Nano-Electron Phys 2014; 6(2): 02006.
[29]
Go MR, Yu J, Bae SH, Kim HJ, Choi SJ. Effects of interactions between ZnO nanoparticles and saccharides on biological responses. Int J Mol Sci 2018; 19: 486.


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Article Details

VOLUME: 4
ISSUE: 3
Year: 2019
Page: [216 - 222]
Pages: 7
DOI: 10.2174/2405461504666191016092835

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