Inflammation is the most common pathology in many orthopedic diseases, such as: rheumatoid
arthritis (RA), osteoarthritis (OA) and other reasons caused osteolysis. The leading factor of
inflammation was considered as the differentiation of monocyte and the polarization of macrophage.
However, cytokines and different cell models could regulate this progress in some aspects. Therefore,
in the current review, we summarize several cytokines and cell models, which could lead to inflammatory
orthopedic diseases via regulating monocytes and macrophages. In order to extensively explore
the potential therapeutic and medicine targets for inflammation-induced bone diseases.
Keywords: Macrophages, cytokines, rheumatoid arthritis, osteoarthritis, osteolysis, monocyte.
Williams H, Cassorla G, Pertsoulis N, Patel V, Vicaretti M, Marmash N, et al. Human classical monocytes display unbalanced
M1/M2 phenotype with increased atherosclerotic risk and presence
of disease. International angiology a journal of the International
Union of Angiology 2017; 36(2): 145-55.
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