Background: Matricaria pubescens is a medicinal plant from North Africa. This plant is
widely used in alternative medicine as a remedy against rheumatism, inflammation, diabetes and hypertension.
Aim: The aim of the study was to evaluate the possible antihypertensive and vasodilator activity of
the aqueous extract of Matricaria pubescens (M. pubescens).
Material and Methods: In the current study, the aqueous extract of the aerial parts of M. pubescens
(AEMP) was prepared and its antihypertensive activity was examined in N(ω)-nitro-L-arginine methyl
ester (L-NAME)-induced hypertensive rats.
Results: The results indicated that AEMP reduced the systolic, diastolic, mean arterial blood pressure
in hypertensive rats but not in normotensive rats. The data revealed that AEMP exhibits its antihypertensive
effect through vasorelaxant activity. More interestingly, this study approved that the vasorelaxant
capacity of AEMP seems to be mediated through vascular cyclooxygenase pathway, the
opening of K+ channels and sGC-cGMP induction pathway.
Conclusion: The study illustrates the beneficial action of M. pubescens as an antihypertensive agent.