Current and Future Developments in Hypertension

Current and Future Developments in Hypertension

Novel Strategies and Approaches in Hypertension Therapy

INTRODUCTION: Hypertension has become a major public health problem in the last few decades. High blood pressure is a serious risk factor for premature cardiovascular disease and end-organ damage ...
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The Link Between Obesity and Hypertension Through Molecular Mechanisms

Pp. 281-302 (22)

Dildar Konukoglu

Abstract

People with a body mass index of 30 kg/m2 or more are considered obese. Obesity is a complex common health problem. It may be the result of several causes and contributing factors and increases the risk of developing a large number of diseases via several mechanisms. Dysregulation of appetite control, endocrine mediators secreted from fat tissue, insulin resistance (IR), elevated oxidative and inflammatory stress, and genetic factors are associated with obesity. There are several factors in obesity related to hypertension, such as increased activity of the renin-angiotensin system (RAS), elevated oxidative stress, and endothelial dysfunction. This is a review of link between obesity and hypertension through molecular mechanisms.

Keywords:

Endothelial Dysfunction, Hypertension, Inflammation, Insulin Resistance, Obesity.

Affiliation:

Department of Biochemistry, Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Istanbul, Turkey.