The Link Between Obesity and Hypertension Through Molecular Mechanisms
Pp. 281-302 (22)
People with a body mass index of 30 kg/m2 or more are considered obese.
Obesity is a complex common health problem. It may be the result of several causes
and contributing factors and increases the risk of developing a large number of diseases
via several mechanisms. Dysregulation of appetite control, endocrine mediators
secreted from fat tissue, insulin resistance (IR), elevated oxidative and inflammatory
stress, and genetic factors are associated with obesity. There are several factors in
obesity related to hypertension, such as increased activity of the renin-angiotensin
system (RAS), elevated oxidative stress, and endothelial dysfunction. This is a review
of link between obesity and hypertension through molecular mechanisms.
Endothelial Dysfunction, Hypertension, Inflammation, Insulin
Department of Biochemistry, Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Istanbul, Turkey.