Current and Future Developments in Hypertension

Current and Future Developments in Hypertension

Novel Strategies and Approaches in Hypertension Therapy

INTRODUCTION: Hypertension has become a major public health problem in the last few decades. High blood pressure is a serious risk factor for premature cardiovascular disease and end-organ damage ...
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Arterial Hypertension in Type 2 Diabetes: Pathogenesis and Treatment

Pp. 160-172 (13)

Mustafa Kanat, Abdulhalim Senyigit and Muhammad A Abdul-Ghani

Abstract

Diabetes and hypertension are increasing worldwide as an important public health problem. There is a fairly common ground that combines diabetes and hypertension. Especially insulin resistance is very important in this respect. Epidemiological data and randomized clinical trials indicate that appropriate treatment of diabetes and hypertension provides a significant reduction in cardiovascular events. For this reason, it is extremely important that these two diseases be handled separately. ACE inhibitors, ARB blockers, calcium channel blockers and thiazide diuretics are the preferred agents in these patients. For patients with albuminuria, ARB or ACEI should be preferred for renoprotective effects. In patients with resistant hypertension, aldosterone antagonists therapy may be added to present therapy.

Keywords:

Aldosterone antagonists therapy, Albuminuria, Arterial hypertension, ACE inhibitors, ARB blockers, Calcium channel blockers, Insulin resistance, Resistant hypertension, Type 2 diabetes, Thiazide diuretics.

Affiliation:

Division of Diabetes, Department of Internal Medicine, University of Istanbul Medeniyet, Goztepe Training and Research Hospital, Istanbul, Turkey.