Current and Future Developments in Hypertension

Current and Future Developments in Hypertension

Novel Strategies and Approaches in Hypertension Therapy

INTRODUCTION: Hypertension has become a major public health problem in the last few decades. High blood pressure is a serious risk factor for premature cardiovascular disease and end-organ damage ...
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Hypertension in Thyroid Disorders

Pp. 139-159 (21)

Lebriz Uslu-Beşli and Pınar Atukeren

Abstract

Although prevalence of hypertension is high in the population, underlying pathology can be determined only in the 10% of the cases and called secondary hypertension. Endocrine disorders are the second most common cause of secondary hypertension after renal diseases. Thyroid diseases are relatively rare causes of secondary hypertension; however, thyroid dysfunction is common in the population. Thyroid hormones affect all physiological systems, including cardiovascular system and blood pressure regulation. Both hypothyroidism and hyperthyroidism can cause hypertension using different mechanisms of action. Hyperthyroidism generally results in increased cardiac output and systolic hypertension, whereas hypothyroidism is associated with increased peripheral vascular resistance, causing diastolic hypertension. As hypertension due to an underlying thyroid disease is reversible if early and adequate therapy is given, thyroid disease related hypertension has to be excluded in hypertensive patients.

This chapter summarizes the present knowledge on the pathogenesis of thyroid disease related hypertension, as well as common thyroid diseases related with hypertension, their diagnosis and treatment alternatives.

Keywords:

Blood pressure, Cardiac output, Diastolic hypertension, Graves’ disease, Hashimoto’s thyroiditis, Hypertension, Hyperthyroidism, Hypothyroidism, Systolic hypertension, Thyroid, Thyrotoxicosis, Thyroid cancer, T3, T4, TSH, TRH, TPO, MIT, DIT, D2 enzyme.

Affiliation:

Department of Medical Biochemistry, Cerrahpaşa Faculty of Medicine, Istanbul University- Cerrahpasa, Istanbul, Turkey.