Genotypic Methods for HIV Drug Resistance Monitoring: The Opportunities and Challenges Faced by China

Author(s): Lulu Zuo, Ke Peng, Yihong Hu*, Qinggang Xu*.

Journal Name: Current HIV Research

Volume 17 , Issue 4 , 2019

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Graphical Abstract:


Abstract:

AIDS is a globalized infectious disease. In 2014, UNAIDS launched a global project of “90-90-90” to end the HIV epidemic by 2030. The second and third 90 require 90% of HIV-1 infected individuals receiving antiretroviral therapy (ART) and durable virological suppression. However, wide use of ART will greatly increase the emergence and spreading of HIV drug resistance and current HIV drug resistance test (DRT) assays in China are seriously lagging behind, hindering to achieve virological suppression. Therefore, recommending an appropriate HIV DRT method is critical for HIV routine surveillance and prevention in China. In this review, we summarized the current existing HIV drug resistance genotypic testing methods around the world and discussed the advantages and disadvantages of these methods.

Keywords: HIV/AIDS, drug resistance test, genotypic methods, antiretroviral therapy, oligonucleotide ligation assay, HIV routine surveillance.

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