Effect of Curcumin on Serum Cathepsin D in Patients with Metabolic Syndrome

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Author(s): Leila Shirmohammadi, Majid Ghayour-Mobarhan*, Maryam Saberi-Karimian, Mehrdad Iranshahi, Shima Tavallaie, Marzieh Emamian, Amirhossein Sahebkar*.

Journal Name: Cardiovascular & Hematological Disorders-Drug Targets
(Formerly Current Drug Targets - Cardiovascular & Hematological Disorders)

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Abstract:

Background/Objective: Inflammatory processes lead to increase the risk of metabolic syndrome (MetS). Cathepsin D is one of the main proinflammatory mediators. In current study, we aimed to investigate the effect of curcumin on serum cathepsin D in patients with MetS.

Materials and Methods: The current study was conducted on 18-65 years old individuals with MetS according to the criteria of "IDF" guidelines. A total of 80 participants were randomly divided into two groups: treatment and control groups. The first group (n=40) were given 2 capsules containing 500mg of phosphatidylcholine complex of curcumin, and the other group (n=40) were given two 500mg capsules contain lactose as placebo for 6 weeks. Before (week 0) and after (week 6) the intervention, anthropometric indices and blood pressure were measured and blood samples were taken. Serum cathepsin D was measured using an abcam ELISA kit.

Results: There were no significant differences between treatment and control groups in regard to weight, BMI, waist circumference and serum cathepsin D levels before and after the intervention. Also, there were no significant differences between pre and post-trial values of serum cathepsin D.

Conclusion: The results shows curcumin has not a significant effect on cathepsin D level in patients with MetS.

Keywords: Curcumin, Cathepsin D, Metabolic Syndrome

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(E-pub Ahead of Print)
DOI: 10.2174/1871529X19666190919110652

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