Background: Along with the description of tumorigenesis processes in endometriosisrelated
ovarian cancer, identifying dysregulated miRNAs, the target genes of these miRNAs, and the
processes abnormally affected by dysregulated miRNAs is essential, which was our goal.
Methods: Two reviewers individually evaluated the articles which collected relevant information including
genes and miRNAs involved in the transformation of endometriosis into ovarian cancer. To
assess the mature sequence of miRNAs and also their chromosomal positions, miRPathDB software
was employed. To determine the main target gene predicted for each considered miRNAs, the TargetScanS
Web server was applied. The interaction of each gene with other genes associated with endometrial-
related ovarian cancer was determined by GeneMANIA software. Finally, to design integrated
model of miRNAs-targeted genes interaction network, the Cytoscape software was used.
Results: The final number of studies available for analysis was 6 manuscripts including 22 miRNAs
described as involved in the transformation of endometriosis into different subtypes of ovarian cancers
(14 miRNAs up-regulated and 8 miRNAs down-regulated). Three miRNAs of miR-141 (upregulated),
miR-205 (down-regulated), and miR-125b (down-regulated) were revealed as the originator
for genetic interactions leading to carcinogenesis. We could show some common loops and pathways
including uncontrolled cell proliferation and abnormal apoptosis (mediated by PTEN gene induced
by miR-21 and miR-214), and disaggregation and epithelialization (mediated by ZEB1 and
ZEB2 genes induced by miR-200).
Conclusion: According to our analysis, up-regulation of miR-141 and down-regulation of miR-205
and miR-125b have a central role in transforming endometriosis to ovarian cancer.