A Systematic Review and Bioinformatics Study on Genes and micro-RNAs Involving the Transformation of Endometriosis into Ovarian Cancer

(E-pub Ahead of Print)

Author(s): Mehrdad Sheikhvatan, Shahla Chaichian*, Bahram Moazzami.

Journal Name: MicroRNA

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Background: Along with description of tumorogenesis processes in endometriosis-related ovarian cancer, identifying dysregulated miRNAs, the target genes of these miRNAs, and the processes abnormally affected by dysregulated miRNAs is essential that was our goal.

Methods: Two reviewers individually evaluated the articles collected relevant information including genes and miRNAs involved in transformation of endometriosis to ovarian cancer. To assess the mature sequence of miRNAs and also their chromosomal positions, miRPathDB software was employed. To determine the main target gene predicted for each considered miRNAs, the TargetScanS Web server was applied. The interaction of each gene with other genes associated with endometrial-related ovarian cancer was determined by GeneMANIA software. Finally, to design integrated model of miRNAs-targeted genes interaction network, the Cytoscape software was used.

Results: The final number of studies available for analysis was 6 manuscripts including 22 miRNAs described as involving in transformation of endometriosis to different subtypes of ovarian cancers (14 miRNAs up-regulated and 8 miRNAs down-regulated). Three miRNAs of miR-141 (up-regulated), miR-205 (down-regulated), and miR-125b (down-regulated) were revealed as the originator for genetic interactions leads to carcinogenesis. We could show some common loops and pathways including uncontrolled cell proliferation and abnormal apoptosis (mediated by PTEN gene induced by miR-21 and miR-214), and disaggregation and epithelialization (mediated by ZEB1 and ZEB2 genes induced by miR-200).

Conclusions: According to our analysis, up-regulation of miR-141 and down-regulation of miR-205 and miR-125b have the central role in transforming endometriosis to ovarian cancer.

Keywords: miRNAs, gene, endometriosis, ovarian cancer, carcinogenesis, cytoscape software

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(E-pub Ahead of Print)
DOI: 10.2174/2211536608666190917152104

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