Mild and Green Protocol for Selective Deuteration of Quercetin-3-ORutinoside (Rutin) Under Aqueous Basic Conditions

Author(s): Anxhela Akolli, Silvia Moretti, Francesca Mangiavacchi, Bonifacio Monti, Claudio Santi*.

Journal Name: Current Green Chemistry

Volume 6 , Issue 2 , 2019

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Abstract:

A convenient and cost-effective method for selective deuteration of rutin using biologically compatible bases and D2O both as a deuterium source and a solvent is herein reported. The protocol is benign and inexpensive affording good results in very mild conditions allowing to reduce the required amount of deuterium oxide. The position of the C-H/C-D exchange and the level of deuteration can be conveniently followed by 1H-NMR.

Keywords: Rutin, arginine, deuterium oxide, NMR, TRIS, solvent.

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Article Details

VOLUME: 6
ISSUE: 2
Year: 2019
Page: [147 - 151]
Pages: 5
DOI: 10.2174/2213346106666190916105514

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