OctaGel Resin - A New PEG-PS-based Solid Support for Solid-Phase Peptide Synthesis

Author(s): Shaveer Ramkisson, Yahaya E. Jad, Anamika Sharma, Beatriz G. de la Torre*, Fernando Albericio*.

Journal Name: Letters in Organic Chemistry

Volume 16 , Issue 12 , 2019

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Abstract:

OctaGel resin is a unique, highly uniformed surface-active resin. Here, we compared the performance of OctaGel with that of known resins on the market, namely polystyrene and ChemMatrix, in Solid-Phase Peptide Synthesis. The synthesis of the ‘difficult’ Aib-ACP (65-74) decapeptide showed that OctaGel has the potential to yield molecules with satisfactory purity. Given its high swelling capacity and large bead size, OctaGel also shows efficient interaction with various solvents, including those mainly used for SPPS (DMF and DCM).

Keywords: Solid-phase peptide synthesis, OctaGel resin, polystyrene resin, Chem matrix, ACP-decapeptide, SEM.

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Article Details

VOLUME: 16
ISSUE: 12
Year: 2019
Page: [935 - 940]
Pages: 6
DOI: 10.2174/1570178616666190913153605
Price: $65

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