Recent Advances and Computational Approaches in Peptide Drug Discovery

Author(s): Neha S. Maurya, Sandeep Kushwaha, Ashutosh Mani*.

Journal Name: Current Pharmaceutical Design

Volume 25 , Issue 31 , 2019

Abstract:

Background: Drug design and development is a vast field that requires huge investment along with a long duration for providing approval to suitable drug candidates. With the advancement in the field of genomics, the information about druggable targets is being updated at a fast rate which is helpful in finding a cure for various diseases.

Methods: There are certain biochemicals as well as physiological advantages of using peptide-based therapeutics. Additionally, the limitations of peptide-based drugs can be overcome by modulating the properties of peptide molecules through various biomolecular engineering techniques. Recent advances in computational approaches have been helpful in studying the effect of peptide drugs on the biomolecular targets. Receptor – ligand-based molecular docking studies have made it easy to screen compatible inhibitors against a target.Furthermore, there are simulation tools available to evaluate stability of complexes at the molecular level. Machine learning methods have added a new edge by enabling accurate prediction of therapeutic peptides.

Results: Peptide-based drugs are expected to take over many popular drugs in the near future due to their biosafety, lower off-target binding chances and multifunctional properties.

Conclusion: This article summarises the latest developments in the field of peptide-based therapeutics related to their usage, tools, and databases.

Keywords: Peptide drugs, therapeutics, druggable-targets, Gonadotropin-releasing hormone, immunoglobulins, drug discovery.

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VOLUME: 25
ISSUE: 31
Year: 2019
Page: [3358 - 3366]
Pages: 9
DOI: 10.2174/1381612825666190911161106
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