Antibiotic resistance is becoming one of the major obstacles to treatment success in various
pathological conditions. Development process of a new antimicrobial agent is slow and difficult,
whereas bacterial resistance is decreasing the arsenal of existing antibiotics. Therefore, there is a need to
develop novel antibiotic formulations to combat the resistance of existing antibiotics. Nanoparticles are
investigated as novel antibiotic formulation, but are often inefficient in practical applications.
Nanotechnology presents a new frontier to overcome the issue of antibiotic resistance through the development
of functionalized particles. Balance of physicochemical characteristics such as small particle
size and high drug loading capacity along with improved stability are the challenges associated with
large scale manufacturing of nanoantibiotic formulations. In the last 1-2 decades, a gradual increase in
patents on nanoantibiotic formulations has been noted to address the resistance issues of antibiotic. The
aim of this review is to consolidate recently-investigated nanoantibiotic formulations to combat antibiotic
Keywords: Antibiotic resistance, drug resistance, infectious diseases, infection, public health, bacterial resistance.
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