Tissue damage repairing and regeneration is a research hot topic. Tissue engineering arises
at the historic moment which is a defect repair compound composed of seed cells, tissue engineering
scaffolds, and inducing factors. Stem cells have a limited growth period in vitro culture, and they have
a pattern of replicating ageing, and these disadvantages are limiting the applications of stem cells in
basic research and clinical treatment. The enhancement of stem cell differentiation ability is a difficult
problem to overcome, and it is possible to enhance the differentiation ability of stem cells through histone
modification so as to provide a more robust foundation for damage repairing and regeneration.
Studies have shown that Histone Deacetylases (HDAC) inhibitors can improve mesenchymal stem cells
in vitro induced in different directions, conversion efficiency, increasing the feasibility and safety of
stem cell therapy and tissue engineering, to offer reference to promote the stem cell therapy in clinical
application. Therefore, this paper mainly focusing on the usage and achievements of the deacetylase
inhibitors in stem cell differentiation studies and their use and prospects in repair of bone tissue defects.
Keywords: Tissue engineering, histone acetylation, histone deacetylases inhibitors, cell differentiation, stem cells, seed cells.
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