Evaluation of Some Biological Applications of Pleurotus citrinopileatus and Boletus edulis Fruiting Bodies

Author(s): Ahmed M. Younis, Marwa M. Abdel-Aziz, Mohamed Yosri*.

Journal Name: Current Pharmaceutical Biotechnology

Volume 20 , Issue 15 , 2019

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Abstract:

Background: Mushrooms are deemed as a special delicacy in many countries. They are considered an important cuisine due to their bioactive ingredients and possible health benefits.

Methods: Herein, we measured selected biological properties of methanol extracts of Pleurotus citrinopileatus and Boletus edulis fruiting bodies including; in vitro antimicrobial activity, anti-α- glucosidase activity, antioxidant activity, anti-lipase activity and cytotoxic activity against different cancer cells and normal cells.

Results: B. edulis methanol extracts showed high antimicrobial and anti-α-glucosidase activity. In contrast, P. citrinopileatus methanol extracts showed superior antioxidant activity indicated by (1,1- diphenyl-2-picrylhydrazyl) DPPH radical scavenging with half maximal inhibitory concentration of IC50 37.4 µg/ml, anti-lipase activities with IC50 65.2 µg/ml and high cytotoxicity activity against HepG2 and HeLa cell lines with IC50 22.8 and 36.7 µg/ml, respectively. Flow cytometric analysis of the cell cycle was used to show apoptotic effects of methanol extracts against HepG2 and HeLa cells.

Conclusion: P. citrinopileatus and B. edulis methanolic extracts appear to contain biologically active compounds that might be used to treat some common human diseases.

Keywords: Pleurotus citrinopileatus, Boletus edulis, antimicrobial activity, antioxidant activity, antitumor activity, anti-α- glucosidase activity, anti-lipase activity, apoptosis.

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VOLUME: 20
ISSUE: 15
Year: 2019
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Pages: 12
DOI: 10.2174/1389201020666190904162403
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