Background: The serum copper (Cu) and ceruloplasmin (Cp) concentrations are
common blood markers of copper metabolism. In altered physiological conditions, Cp can
act as an acute phase reactant and its concentration may increase.
Objective: To evaluate specific enzymatic activity of Cp as a potential indicator of Cu status
and its correlation with serum Cu level.
Methods: Serum Cu levels were estimated as per NIOSH method. Specific enzymatic activity
of Cp was determined from enzymatic activity and immune concentration of Cp as per
standard methods. The statistical analysis was carried out using the package of social science
Results: The difference in mean specific enzymatic activity of Cp was statistically significant
between clinical and control groups. In control population, the correlation between serum
Cu level and specific enzymatic activity of Cp was moderate and statistically significant
(r=0.566, p=0.014, N=18) as compared to the clinical group (r=0.338, p=0.016, N=50).
Conclusion: The study revealed that clinical group was significantly different in specific enzymatic
activity of Cp as compared to control group. Besides this, the specific enzymatic activity
of Cp was moderately but significantly correlated with serum Cu level in control group
but did not reveal conclusive evidence in clinical population.