Vitamin C Loaded Chemically Modified Nano Carrier for Human Health Care Application

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Author(s): Monalisha Sengupta*, Md. Adil Shaharyar, Kumar Anand, Anindita Kundu.

Journal Name: Current Biochemical Engineering

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Abstract:

Background: “Health is wealth” and to maintain it 7 essential nutrients are required. Among these Vitamin is one has great importance in very low concentration. As per the solubility it divides into water soluble and water insoluble vitamins. This study concentrates on Vitamin C, a water soluble vitamin which is essential for human growth due to its activity in synthesis of carnitine, collagen and neurotransmitter. It possesses anti-oxidant, antiatherogenic, and immunomodulator functions, which may lead to the activity of Vitamin C in many diseases. But human and some other non human primates are unable to produce Vitamin C from glucose, due to the absence of enzyme gulonolactone oxidase. As a result, humans are depended on various dietary sources of Vc specially citrus fruit. But these dietary supplies also fail to achieve the required level at body due to its poor bioavailability and storage.

Method: Vitamin C has already proven its activity in the cancer therapy. Also it is used as prodrug of H2O2. But due to the poor bioavailability and storage of Vitamin C in human body mankind are unable to avail the benefits of Vitamin C. These problems lead to generate different and suitable nanoformulations to incorporate Vitamin C and its derivatives into it. Different research work shows several ways to develop nanoformulations. Amongst all liposomes, microsphere, nanocarriers are of great importance. For Vitamin C incorporation into the nanoformulation, nanocarriers become the most popular choice for researchers. There were several nanocarrier systems developed using Chitosan-Alginate, Silica-Coated-Au Nanoparticles, Chitosan, Mesoporous-silica NCs for suitable incorporation of Vitamin C into these. The performances were assured by performing different in-vitro and in-vivo tests which will be discussed here.

Result: As a result Vitamin C is now in the use for many purposes. It includes not only the above mentioned functions but also other functions too. Due to an antioxidant property Vitamin C is able to quenches reactive oxygen species (ROS), by inhibiting ROS-mediated nitric oxide (NO) inactivation. Vitamin C helps to elevate the level of absorption of iron within the cell from dietary iron sources. It also prevents the oxidation of drugs. To achieve all these functions, NCs or the nanoformulation plays a great role.

Conclusion: It can be concluded that depending on the biocompatibility, loading capacity, protection of the loading molecule, efficiency of cellular uptake, controllable rate of release to achieve the desired effect and many more factors; the choice of different nanocarriers (NCs) will be done which ultimately help the human to use it for different purposes. This paper tries to gather some information in one place with respect to compare different experimental studies.

Keywords: Vitamin C (Vc), Nanocarriers (NCs), Nanoparticles (NPs), Chitosan, anti-oxidant, controlled release.

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(E-pub Ahead of Print)
DOI: 10.2174/2212711906666190903113903

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