Background: The microbiome plays a very important role in many physiological
processes including metabolism, inflammation, homeostasis and many biological pathways.
Therefore, dysbiosis of the microbiome disrupts these pathways in different ways that may result
in causing cancer. There is a complex connection between the microbiome and cancer. The human
bodies are continuously exposed to microbial cells, both resident and transient, as well as their
byproducts, including toxic metabolites.
Objective: To develop the manually curated, searchable and metagenomic resource to facilitate the
investigation of Human Cancer microbiota and make it publicly accessible through a web interface
which will help further in metagenomic studies.
Methods: In HOBD, the information on different cancers (Oral Cancer, Breast Cancer, Liver
Cancer, and Colorectal Cancer) has been compiled. The main purpose of creating HOBD was to
provide the scientific community with comprehensive information on the species that play a
crucial role in various Human Cancers.
Result: Over time, this resource will grow to become a unique community resource of human
cancer bacteria, providing an extra level of annotation for the analysis of metagenomic datasets.
Conclusion: The HOBD site offers easy to use tools for viewing all publicly available Human
Cancer microbiota. The freely accessible website is available at http://www.juit.ac.in/hcmd/home.