Background: Terebinthus atlanticus (Anacardiaceae) is an important source of essential
oil and phenolic compounds justifying its use in traditional medicine.
Objective: The present work aimed to evaluate the antidiabetic and the antioxidant activities of the
aqueous extract of the leaves of Terebinthus atlanticus (T. atlanticus).
Methods: The current study evaluated the effect of a single and repeated (15 days of treatment) oral
administration of the aqueous extract of the leaves of T. atlanticus (PALAE) on blood glucose levels
in normal and streptozotocin(STZ)-induced diabetic rats. Furthermore, the effect of PALAE on
glucose tolerance and histopathological examination of the liver was carried out.
Results: A single oral administration of PALAE reduced blood glucose levels in normal (p<0.05),
and STZ diabetic rats (p<0.0001), 6 and 4 hours after administration, respectively. Furthermore, this
extract had an optimal effect (p<0.0001) in both normal and STZ diabetic rats at the 15th and 7th day
of treatment. This extract was also shown to prevent significantly the increase on blood glucose
levels 120 min after glucose administration, in both normal (p<0.05), and diabetic (p<0.01) treated
rats when compared to the control group. In addition, the histopathological analysis highlighted the
positive effect of T. atlanticus on pancreas and liver.
Conclusion: The study demonstrates the antihyperglycemic effect of the aqueous T. atlanticus extracts
in diabetic rats which should be mediated through the amelioration of the oxidative stress as
well as an improvement in liver histology.