Natural Antimutagens. Chemopreventive Action of L-Ascorbic Acid and Green Tea Infusions on the Acute Toxicity and Mutagenicity of Reaction Mixtures Nitrite-Sulfonamide
Pp. 46-90 (45)
Ana Pontoriero and Marcela Rizzotto
An agent that causes irreversible and hereditary (mutation) changes in
cellular genetic material, deoxyribonucleic acid (DNA) is defined as a mutagen.
Changes in DNA caused by mutagens can damage the cells and cause certain diseases,
such as cancer. Among the oldest and most recognized tests for the detection of
mutagens we can mention those of Ames, which works with bacteria, and the test of the
onion or Allium cepa test. One of the most effective ways to minimize the harmful
effect of mutagenic substances is through the use of natural antimutagens. Natural
antimutagenic substances, which may be present in plants, human diet and other
sources have protective effects against mutagens. We showed that vitamin C and green
tea infusions, in the Ames test, significantly mitigate the mutagenicity of sulfatiazole (a
sulfa drug, an antibacterial commonly used) and nitrite (a food preservative and a
normal body component) mixtures in acidic medium.
Chemoprevention, Mutagen, Natural antimutagens, Nitrite,
Instituto de Química Rosario (IQUIR), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Argentina.