Objective: Asthma is correlated with a higher risk of manifesting other diseases, including
hypertension, diabetes, obesity, psychiatric and neurological diseases, and cancer. Therefore, revealing
this interplay between asthma and these illnesses may provide novel insights into their pathogenesis.
Results: It is highly debated that dysregulation of Ca2+ homeostasis is involved in the pathogenesis of
these maladies. Not surprisingly, calcium (Ca2+) channel blockers (CCBs), classically used as antihypertensive
medicines, have been demonstrating off-label effects such as alleviating asthma symptoms,
in addition to antidiabetic, antiobesity, anticancer and antineurodegenerative effects. Our studies
about Ca2+/cAMP signalling may shed some new light on this field.
Conclusion: Thus, considering that asthma and associated illnesses such as hypertension, diabetes,
obesity, cancer and neurodegenerative diseases have become highly prevalent medical problems in the
world, the comprehension of this interplay between asthma and other disorders could improve drug