Harnessing Stem Cell Potential for the Treatment of Erectile Function with Diabetes Mellitus: From Preclinical/Clinical Perspectives to Penile Tissue Engineering

Author(s): Serap Gur, Wayne J.G. Hellstrom*.

Journal Name: Current Stem Cell Research & Therapy

Volume 15 , Issue 4 , 2020

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Abstract:

Background: According to the World Health Organization, more than 150 million people are diabetic, and this number will increase twofold by the year 2025. Diabetes-related complications affect all body organ systems, including the penis. Diabetes-induced Erectile Dysfunction (ED) is caused by neuropathy of the penile nerves and vasculopathy involving the smooth muscle and endothelium of the corpus cavernosum.

Objective: This study aims to present an overview of Stem Cell (SC) research in diabetic animal models of ED, focusing on the function, signaling, and niches that have a prominent role in the regeneration of cavernosal cells and penile tissues. We highlight common erectile pathologies caused by diabetes and review relevant preclinical trials. We also discuss paracrine mechanisms of various SC therapies involved in the repair of endothelial cells and cavernous nerves in these diabetic models.

Methods: A PubMed search was performed, with dates ranging from inception until Mar 31, 2019.

Results: This review provides a comprehensive evaluation of the various strategies that have been investigated for improving SC delivery methods, through preclinical literature and published clinical trials regarding ED in men with diabetes. Various cell-type applications have benefited erectile function in diabetic models of ED.

Conclusion: This review examines the progress and remaining challenges in diabetes-related SC research regarding ED. Moving forward, it is only with a combined effort of basic biology and translational work that the potential of SC-based therapies in diabetes in ED can be realized.

Keywords: Stem cell, diabetes mellitus, preclinical, erectile dysfunction, clinical trials, tissue engineering.

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Article Details

VOLUME: 15
ISSUE: 4
Year: 2020
Page: [308 - 320]
Pages: 13
DOI: 10.2174/1574888X14666190828142045
Price: $95

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