Associations of CYP2A6 Gene Polymorphism with Smoking Status Among Jordanians: Gender-Related Differences

Author(s): Hana M. Hammad*, Amer Imraish, Belal Azab, Al M. Best, Yousef S. Khader, Malek Zihlif.

Journal Name: Current Drug Metabolism

Volume 20 , Issue 9 , 2019


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Abstract:

Background: Cytochrome P450 2A6 enzyme (CYP2A6), an essential hepatic enzyme involved in the metabolism of drugs, is responsible for a major metabolic pathway of nicotine. Variation in the activity of polymorphic CYP2A6 alleles has been implicated in inter-individual differences in nicotine metabolism.

Aims: The objective of the current study was to assess the association between the smoking status and the cytochrome P450 2A6 enzyme (CYP2A6) genotype in Jordanians.

Methods: In the current study, 218 (117 Male and 101 female) healthy unrelated Jordanian volunteers were recruited. CYP2A6*1B, CYP2A6*4 and CYP2A6*9 were determined and correlated with subject smoking status.

Results: *1A/*1A was the most common genetic polymorphism in the overall study population, with no significant frequency differences between smokers and non-smokers. When the population was divided according to gender, only male smokers showed a significant correlation between genotype and smoking status. Considering the CYP2A6*9 genotype, the results showed differences in distribution between smokers and non-smokers, but only women showed a significant association between CYP2A6*9 allele genotype and smoking status.

Conclusion: The results of this study show that there is a significant association between CYP2A6*9 genotype and smoking status. They also show that CYP2A6 genotype is significantly influenced by gender.

Keywords: CYP2A6, polymorphisms, drug metabolism, nicotine, smoking behavior, Jordanians, gender-related differences.

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Article Details

VOLUME: 20
ISSUE: 9
Year: 2019
Page: [765 - 770]
Pages: 6
DOI: 10.2174/1389200220666190827161112
Price: $58

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