Contact lens wear is generally safe and provides excellent vision. However, contact lens wear
is often associated with the risk of developing ocular surface infection and inflammation, and in severe
cases, the infection can result in loss of vision. Antimicrobial peptide-coated contact lenses have been
made to help reduce the incidence of infection and inflammation. This paper reviews the research progress
from conception, through the laboratory and preclinical tests to the latest information on clinical
testing of an antimicrobial contact lens. We provide insights into the pathways followed and pitfalls that
have been encountered. The journey has not always been linear or smooth, but has resulted in some of
the first published clinical testing of antimicrobial peptide-coated contact lenses in humans. We hope
this may help lead to the development and commercialisation of antimicrobial contact lenses in the future.
Keywords: Contact lens, keratitis, antimicrobial peptide, clinical trial, melamine, MeL4.
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