Scientific Papers and Patents on Substances with Unproven Effects. Part 2

(E-pub Ahead of Print)

Author(s): Sergei V. Jargin*.

Journal Name: Recent Patents on Drug Delivery & Formulation

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This review discusses several examples, where substances without proven effects were proposed for practical use within the scope of evidence-based medicines. The following is discussed here: generalizations of the hormesis concept and its use in support of homeopathy; phytoestrogens and soy products potentially having feminizing effects; glycosaminoglycans for the treatment of osteoarthritis and possibilities of their replacement by diet modifications; flavonoids recommended for the treatment of chronic venous insufficiency and varicose veins; acetylcysteine as a mucolytic agent and its questionable efficiency especially by an oral intake; stem cells and cell therapies. In conclusion, placebo therapies can be beneficial and ethically justifiable but it is not a sufficient reason to publish biased information. Importantly, placebo must be devoid of adverse effects, otherwise, it is named pseudoplacebo. Therapeutic methods with unproven effects should be tested in high-quality research shielded from the funding bias. Some issues discussed in this review are not entirely clear, and the arguments provided here can initiate a constructive discussion.

Keywords: Placebo, hormesis; nutrition, phytoestrogens, soy, osteoarthritis, acetylcysteine

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(E-pub Ahead of Print)
DOI: 10.2174/1872211313666190819124752

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