An Updated Review of Disulfiram: Molecular Targets and Strategies for Cancer Treatment

Author(s): Qingzhu Yang, Yao Yao, Kai Li, Lin Jiao, Jiazhen Zhu, Cheng Ni, Mengmeng Li, Q. Ping Dou*, Huanjie Yang*.

Journal Name: Current Pharmaceutical Design

Volume 25 , Issue 30 , 2019


Abstract:

Repurposing already approved drugs as new anticancer agents is a promising strategy considering the advantages such as low costs, low risks and less time-consumption. Disulfiram (DSF), as the first drug for antialcoholism, was approved by the U.S. Food and Drug Administration (FDA) over 60 years ago. Increasing evidence indicates that DSF has great potential for the treatment of various human cancers. Several mechanisms and targets of DSF related to cancer therapy have been proposed, including the inhibition of ubiquitin-proteasome system (UPS), cancer cell stemness and cancer metastasis, and alteration of the intracellular reactive oxygen species (ROS). This article provides a brief review about the history of the use of DSF in humans and its molecular mechanisms and targets of anticancer therapy, describes DSF delivery strategies for cancer treatment, summarizes completed and ongoing cancer clinical trials involving DSF, and offers strategies to better use DSF in cancer therapies.

Keywords: Disulfiram, cancer, molecular targets, drug delivery, clinical trials, anticancer agents.

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VOLUME: 25
ISSUE: 30
Year: 2019
Page: [3248 - 3256]
Pages: 9
DOI: 10.2174/1381612825666190816233755
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