Vitamin D and Vitamin D Receptor: New Insights in the Treatment of Hypertension

Author(s): Lin Lin , Lei Zhang , Chao Li , Zhibo Gai* , Yunlun Li* .

Journal Name: Current Protein & Peptide Science

Volume 20 , Issue 10 , 2019

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Graphical Abstract:


Abstract:

Vitamin D, as a natural medicine, is known to regulate calcium and phosphate homeostasis. But abundant research has shown that vitamin D also plays a regulatory role in autoimmunity, inflammation, angiogenesis and vascular cell activity. Since the vitamin D receptor (VDR) is widely distributed in vascular endothelial cells, vascular smooth muscle cells and cardiomyocytes, the role of vitamin D and VDR in hypertension has received extensive attention. Hypertension is a disease with high incidence and high cardiovascular risk. In recent years, both clinical trials and animal experiments have shown that vitamin D plays a regulatory role in decreasing blood pressure (BP) through inhibiting renin-angiotensin-aldosterone system activity, modulating function of vascular wall and reducing vascular oxidative stress. A growing body of data suggest that vitamin D deficiency is associated with increased cardiovascular disease risk in hypertension, even short-term vitamin D deficiency may directly raise BP and promote target organ damage. Due to the high correlation between vitamin D and hypertension, vitamin D supplementation therapy may be a new insight in the treatment of hypertension. The aim of this review will explore the mechanisms of the vitamin D and VDR in regulating the BP and protecting against the target organ damage.

Keywords: Vitamin D, vitamin D receptor, hypertension, hypertensive organ damage, therapeutic targets, cardiovascular risk.

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VOLUME: 20
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Year: 2019
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DOI: 10.2174/1389203720666190807130504
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