Allergic diseases are assuming increasing trend of prevalence worldwide. The diseases confer
increasing demand on medical and healthcare facilities. Patients with allergies have poor quality of
life and impaired cognition. Adult patients have subpar working efficiency while afflicted children are
less effective at school, often have school absenteeism and need more attention of their caregivers. All
of them lead to negative socio-economic impact. This narrative review focuses on cockroach allergy
including currently recognized cockroach allergens, pathogenic mechanisms of allergy, componentresolved
diagnosis and allergen-specific immunotherapy, particularly the component-resolved immunotherapy
and the molecular mechanisms that bring about resolution of the chronic airway inflammation.
Keywords: Allergens, cockroach, component-resolved diagnosis (CRD), component-resolved immunotherapy, (CRIT), Th2
response, tissue remodeling.
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