Background: Nanotechnology brings innovation in the healthcare sector and revolutionized
the therapeutic domain in recent years. It provides better health facilities and bring advancement in the
field of science and technology. Nanocarriers are extremely small structure and involve synthesis, designing,
application of medicament in the size range of 1-100 nm. Nanocarriers are especially explored
for their chemical, physical and biological activity. Good understanding of all these properties
is necessary to increase the therapeutic application of nanocarriers in different fields, by abating the
hazards to creatures and the environment. The goal of this article is to review the developed nanocarriers
of Umbelliferone from the viewpoints of research trend, synthesis, targeting mechanism, its clinical
applications and future perspective.
Methods: A wide variety of nanocarriers system of umbelliferone have been developed, such as
nanoshell, nanowire, nanoparticles, solid lipid nanostructure, dendrimers, nanoemulsion, nanosponges,
etc. Nanosystem of umbelliferone is prepared by two approaches i.e. top-up and bottom down method,
as well as their potential application in several areas, is presented in this paper.
Results: Umbelliferone, a 7-hydroxycoumarin is widely available Rutaceae and Apiaceae families and
termed as a therapeutic active agent. It is a derivative of coumarin and contain a heterocyclic ring with
the improved biological property. In the literature survey, antifungal, antibacterial, antihyperglycaemic,
anti-cancer, anti-diabetic, anti-arthritic, antioxidant and anti-inflammatory property
are reported. Nanocarriers encapsulated umbelliferone have been recommended and explored to treat
various types of diseases.
Conclusion: This article upsurges the understanding of the nano-based delivery system of drug Umbelliferone
in the field of biomedical application along with the safety concerns. A future perspective
on the fabrication of nanocarriers of umbelliferone, scaling up technique, therapeutic efficacy and environmental
protection is presented in the review. This advocates that numerous possible application
of this drug for the future works are available for the commercialization.