Umbelliferone Loaded Nanocarriers for Healthcare Applications

(E-pub Ahead of Print)

Author(s): Deepika Singh*, Mahfoozur Rahman.

Journal Name: Current Biochemical Engineering

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Background: Nanotechnology bring innovation in healthcare sector and revolutionized the therapeutic domain in a recent years. It provides better health facilities and bring advancement in the field of science and technology. Nano carriers are extremely small structure and involves synthesis, designing, application of medicament in the size range of 1-100 nm. Nano carriers are especially explored for their chemical, physical and biological activity. Good understanding of all these properties is necessary to increasing the therapeutic application of nano carriers in different fields, by abating the hazards to creatures and environment. The goal of this article is to review the developed nano carriers of Umbelliferone from the viewpoints of research trend, synthesis, targeting mechanism, its clinical applications and future perspective.

Method: A wide variety of nano carriers system of umbelliferone have been developed, such as nanoshell, nanowire, nanoparticles, solid lipid nanostructure, dendrimers, nanoemulsion, nanosponges and etc. nanosytem of umbelliferone is prepared by two approach i.e. top-up and bottom down method as well as their potential application in several areas are presented in this paper.

Results: Umbelliferone, a 7-hydroxycoumarin is widely available Rutaceae and, Apiaceae families and termed as a therapeutic active agent. It is derivative of coumarin and contain heterocyclic ring with improved biological property. In the literature survey, antifungal, antibacterial, anti-hyperglycaemic, anti-cancer, anti-diabetic, anti-arthritic, antioxidant and anti-inflammatory property are reported. Nano carriers encapsulated umbelliferone have been recommended and explored to treat various types of diseases

Conclusion: This article upsurges the understanding of nano based delivery system of drug Umbelliferone in the field of biomedical application along with the safety concerns. Future perspective on fabrication of nanocarriers of umbelliferone, scaling up technique, therapeutic efficacy and environmental protection are presented in the review. This advocates that numerous possible application of this drug for the future works are available for the commercialization.

Keywords: Umbelliferone, Nanocarriers, Healthcare Applications, Nanotechnology, Therapeutic domain, Science and technology

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/2212711906666190730100144