The article provides an overview of current views on the role of biomechanical forces in
the pathogenesis of atherosclerosis. The importance of biomechanical forces in maintaining vascular homeostasis is considered. We provide descriptions of mechanosensing and mechanotransduction. The roles of wall shear stress and circumferential wall stress in the initiation, progression and destabilization of atherosclerotic plaque are described. The data on the possibilities of assessing biomechanical factors in clinical practice and the clinical significance of this approach are presented. The article concludes with discussion current therapeutic approaches based on the modulation of biomechanical forces.
Keywords: atherosclerosis, wall shear stress, peripheral artery disease, circumferential wall stress, mechanosensing, plaque progression
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