Aptamers in Drug Design: An Emerging Weapon to Fight a Losing Battle

Author(s): Jobin Jose, Aaron Mathew Thomas, Darewin Mendonsa, Mohammad M. Al-Sanea, Md. Sahab Uddin, Della Grace Thomas Parambi, R Narayana Charyulu, Bijo Mathew*.

Journal Name: Current Drug Targets

Volume 20 , Issue 16 , 2019

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Graphical Abstract:


Implementation of novel and biocompatible polymers in drug design is an emerging and rapidly growing area of research. Even though we have a large number of polymer materials for various applications, the biocompatibility of these materials remains as a herculean task for researchers. Aptamers provide a vital and efficient solution to this problem. They are usually small (ranging from 20 to 60 nucleotides, single-stranded DNA or RNA oligonucleotides which are capable of binding to molecules possessing high affinity and other properties like specificity. This review focuses on different aspects of Aptamers in drug discovery, starting from its preparation methods and covering the recent scenario reported in the literature regarding their use in drug discovery. We address the limitations of Aptamers and provide valuable insights into their future potential in the areas regarding drug discovery research. Finally, we explained the major role of Aptamers like medical imaging techniques, application as synthetic antibodies, and the most recent application, which is in combination with nanomedicines.

Keywords: Aptamers, Drug design, Oligonucleotides, Nanomedicine, Synthetic antibodies, nucleotides.

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Year: 2019
Page: [1624 - 1635]
Pages: 12
DOI: 10.2174/1389450120666190729121747
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