Background: Mild Parkinsonian Signs (MPS) have been associated with Mild Cognitive Impairment
(MCI) types with conflicting results.
Objective: To investigate the association of individual MPS with different MCI types using logistic
ridge regression analysis, and to evaluate for each MCI type, the association of MPS with caudate atrophy,
global cerebral atrophy, and the topographical location of White Matter Hyperintensities (WMH),
Methods: A cross-sectional study was performed among 1,168 subjects with different types of MCI
aged 45-97 (70,52 ± 9,41) years, who underwent brain MRI. WMH were assessed through two visual
rating scales. The number and location of lacunes were also rated. Atrophy of the caudate nuclei and
global cerebral atrophy were assessed through the bicaudate ratio, and the lateral ventricles to brain ratio,
respectively. Apolipoprotein E (APOE) genotypes were also assessed. Using the items of the motor
section of the Unified Parkinson’s Disease Rating Scale, tremor, rigidity, bradykinesia, and
gait/balance/axial dysfunction were evaluated.
Results: Bradykinesia, and gait/balance/axial dysfunction were the MPS more frequently encountered
followed by rigidity, and tremor. MPS were present in both amnestic and non-amnestic MCI types, and
were associated with WMH, lacunes, bicaudate ratio, and lateral ventricles to brain ratio.
Conclusion: MPS are present in both amnestic and non-amnestic MCI types, particularly in those multiple
domain, and carrying the APOE ε4 allele. Cortical and subcortical vascular and atrophic processes
contribute to MPS. Long prospective studies are needed to disentangle the contribution of MPS to the
conversion from MCI to dementia.