Synthetic Approach for Substituted 3-amino-1,2,4-triazines and their Chemical Reactivity and Biological Properties

(E-pub Ahead of Print)

Author(s): Reda Abdel Rahman , Mohammed A. Assiri , Ahmed M. Fouda , Tarik E. Ali* .

Journal Name: Mini-Reviews in Organic Chemistry

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3-Amino-1,2,4-triazines are considered versatile compounds for its significance as building blocks in synthetic and pharmaceutical chemistry. The synthesis, chemical reactivity, and applications of substituted 1,2,4-triazines bearing an amino group were described in this review. The presence of the amino group at position 3 exhibited unique reactivities towards carbonitrile, carbonyl and isothiocyanate reagents. The reactions were divided into several categories, depending on the other substituents on the 1,2,4-triazine ring. In this review, relevant and appropriate applications of the synthesized, isolated, and condensed heterocycles derivatives were reported.

Keywords: Synthesis, 3-amino-1, 4-triazines, reactivity, pharmacological., chemical reactivity

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/1570193X16666190724105040
Price: $95