A Mini-Review: Achievements in the Thiolysis of Epoxides

Author(s): Zhihua Chen, Saeed Mohammadi Nasr, Mosstafa Kazemi*, Masoud Mohammadi.

Journal Name: Mini-Reviews in Organic Chemistry

Volume 17 , Issue 4 , 2020

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The β-hydroxy sulfides are an important class of organosulfur compounds that have a key role in the synthesis of bioactive compounds containing biological and natural products. The thiolysis of epoxides is the most common and best route for the synthesis of β-hydroxy sulfides. During the last decade, the applications of a diverse range of catalysts and promoter agents in green and organic mediums as well as under solvent-free conditions for the regioselective ring-opening reactions of epoxides with thiols in order to synthesize β-hydroxy sulfides have been studied by various research groups. This review is focused on the important achievements reported in the literature for the thiolysis of epoxides.

Keywords: Biological, epoxides, organosulfur compounds, thiolysis, β-hydroxy sulfides, catalysts.

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Article Details

Year: 2020
Page: [352 - 362]
Pages: 11
DOI: 10.2174/1570193X16666190723111746
Price: $95

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