Background: This paper describes the synthesis of novel thiazolidin-4-one substituted pyrazole derivatives
from the condensation reaction of hyrazide with acetophenone derivatives. Herein we describe the synthesis of
fourteen compounds by microwave irradiation method. The synthesized compounds are in excellent yield by
utilizing microwave irradiation heating.
Objective: Compounds using different aromatic or heteroaromatic compounds should be synthesized and
screened for their antibacterial activity to explore the possibility of pyrazole substituted thiazolidin- 4-ones as a
novel series of antimicrobials.
Method: Synthesis of thiazolidin-4-one substituted pyrazole derivatives was carried out under microwave
Result: These compounds were identified on the basis of melting point range, Rf values, IR, 1H-NMR and mass
spectral analysis. These compounds were evaluated for their in vitro antimicrobial activity and their minimum
inhibitory concentration (MIC) was determined. Among them Comp. 4b and Comp. 4k possess appreciable
antimicrobial and antifungal activities.
Conclusion: A novel series of Thiazolidin-4-one substituted pyrazole were synthesized under microwave
irradiation method and identified on the basis of melting point range, R f values, IR, 1H-NMR, mass spectral data
and elemental analysis. The compounds were subjected to in vitro antimicrobial screening and their minimum
inhibitory concentrations (MIC) were determined. Among all the tested compounds, two compounds 4b and 4k
exhibited moderate to significant activity against all the tested strains of bacteria and fungus were found to have
appreciable antimicrobial activities. The results of antibacterial activity showed that compounds containing
electron withdrawing groups were found to be more active than the compounds containing electron releasing