Therapeutic Promises of Chlorogenic Acid with Special Emphasis on its Anti-Obesity Property

Author(s): Rajnish Kumar, Anju Sharma, Mohammed Shariq Iqbal, Janmejai K. Srivastava*.

Journal Name: Current Molecular Pharmacology

Volume 13 , Issue 1 , 2020

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Graphical Abstract:


Abstract:

Background: Chlorogenic acid (CGA) is a quinic acid conjugate of caffeic acid. It is an ester formed between caffeic acid and the 3-hydroxyl of L-quinic acid. This polyphenol is naturally present in substantial amount in the green coffee beans. Minor quantities of CGA are also reported in apples, eggplant, blueberries, tomatoes, strawberries and potatoes. CGA is reported to be beneficial in hypertension, hyperglycemia, antimicrobial, antitumor, memory enhancer, weight management etc. Further, it is also reported to have anticancer, antioxidant and anti-inflammatory activities. Since the last decade, CGA drew public attention for its widely recommended use as a medicine or natural food additive supplement for the management of obesity.

Objective: The current review explores the medicinal promises of CGA and emphasizes on its antiobese property as reported by various scientific reports and publication.

Conclusion: CGA shows promises as an antioxidant, glycemic control agent, anti-hypertensive, antiinflammatory, antimicrobial, neuro-protective and anti-obesity agent. It primarily activates the AMPactivated protein kinase, inhibits 3-hydroxy 3-methylglutaryl coenzyme-A reductase and strengthens the activity of carnitine palmitoyltransferase to control the obesity.

Keywords: Chlorogenic acid, coffee, lipid, medicinal activity, obesity, CPT.

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