Dendrimer Based Nanoarchitectures in Diabetes Management: An Overview

Author(s): Vijay Mishra, Nishika Yadav, Gaurav K. Saraogi, Murtaza M. Tambuwala, Namita Giri*.

Journal Name: Current Pharmaceutical Design

Volume 25 , Issue 23 , 2019

Abstract:

Diabetes has turned out to be one of the biggest worldwide health and economic burdens, with its expanded predominance and high complexity proportion. The quantity of diabetic patients is expanding enormously around the world. Several reports have demonstrated the sharp increment in the sufferers. Stable and acceptable blood glucose control is fundamental to diminish diabetes-related complications. Consequently, ceaseless endeavors have been made in antidiabetic drugs, treatment strategies, and nanotechnology based products to accomplish better diabetes control. The nanocarriers pertaining hypoglycaemics provide improved diabetes management with minimum risk of associated side effects. Dendrimers have caught an incredible attention in the field of drug delivery and personalized medicines. Dendrimers are three-dimensional well-defined homogenous nanosized structures consisting tree-like branches. The present review highlights the different aspects of dendrimers including fabrication, surface engineering, toxicological profile as well as delivery of antidiabetic drugs for the effective cure of diabetes.

Keywords: Diabetes, dendrimer, drug delivery, toxicity, nanocarrier, toxicological profile.

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VOLUME: 25
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Year: 2019
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