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Current Chemical Biology

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ISSN (Print): 2212-7968
ISSN (Online): 1872-3136

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Current Frontiers

Emerging Marine Immunomodulatory Small-molecules (2010- Present)

Author(s): Ran Li, Yu-Cheng Gu and Wen Zhang*

Volume 13, Issue 3, 2019

Page: [187 - 196] Pages: 10

DOI: 10.2174/2212796813666190716102614

Abstract

Background: Immunomodulation-based therapy has achieved a breakthrough in the last decade, which stimulates the passion of searching for potential immunomodulatory substances in recent years.

Objective: Marine natural products are a unique source of immunomodulatory substances. This paper summarized the emerging marine natural small-molecules and related synthesized derivatives with immunomodulatory activities to provide readers an overview of these bioactive molecules and their potential in immunomodulation therapy.

Conclusion: An increasing number of immunomodulatory marine small-molecules with diverse intriguing structure-skeletons were discovered. They may serve as a basis for further studies of marine natural products for their chemistry, related mechanism of action and structure- activity relationships.

Keywords: Marine small-molecules, immunomodulator, immunostimulant, immunosuppressant, α- GalCer, Polyketides.

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