Background: Immunomodulation-based therapy has achieved a breakthrough in
the last decade, which stimulates the passion of searching for potential immunomodulatory
substances in recent years.
Objective: Marine natural products are a unique source of immunomodulatory substances.
This paper summarized the emerging marine natural small-molecules and related synthesized
derivatives with immunomodulatory activities to provide readers an overview of these bioactive
molecules and their potential in immunomodulation therapy.
Conclusion: An increasing number of immunomodulatory marine small-molecules with diverse
intriguing structure-skeletons were discovered. They may serve as a basis for further
studies of marine natural products for their chemistry, related mechanism of action and structure-