Engineering of Exosomes: Steps Towards Green Production of Drug Delivery System

(E-pub Ahead of Print)

Author(s): Abdelrahman Y. Sherif*, Gamaleldin I. Harisa, Fars K. Alanazi, Abdullah M.E. Youssof.

Journal Name: Current Drug Targets

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Abstract:

Targeting of therapeutic agents to their specific site of action not only increases the treatment efficacy, but also reduces systemic toxicity. Therefore, various drug delivery systems (DDSs) have been developed to achieve this target. However, most of those DDSs have several issues regarding biocompatibility and environmental hazard. In contrast to the synthetic DDSs, exosome-based natural carriers are biocompatible, biodegradable and safe for the environment. Since exosomes play a role in intercellular communication, they have been widely utilized as carriers for different therapeutic agents. This article was aimed to provide an overview of exosomes as an environment-friendly DDS in terms of engineering, isolation, characterization, application and limitation.

Keywords: Drug targeting, Biological DDS, Green DDS, Exosome, Bionanocarriers, vesicular carrier.

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/1389450120666190715104100
Price: $95

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