Background: Cardiac disease is accounted as the leading cause of worldwide morbidity and mortality.
The disease is characterized by the overproduction of reactive oxygen and/or nitrogen species (ROS/RNS), and
induction of oxidative stress. Cannabidiol (CBD) is a non-psychoactive ingredient of marijuana that has been
reported to be safe and well tolerated in patients. Due to its pleiotropic effect, CBD has been shown to exert cytoprotective
effects. This study intended to clarify the mechanisms and the potential role of CBD regarding cardiac
Methods: A systematic literature search was conducted, according to the Preferred Reporting Items for Systematic
Reviews and Meta-Analyses (PRISMA) guidelines, in the electronic databases including PubMed, Web of
Science, Scopus, and Embase up to June 2019 using predefined search terms in the titles and abstracts. Accordingly,
a set of pre-specified inclusion and exclusion criteria were considered and 8 articles were ultimately included
in this study.
Results: Our findings demonstrate that CBD has multi-functional protective assets to improve cardiac injuries;
preliminary through scavenging of free radicals, and reduction of oxidative stress, apoptosis, and inflammation.
Conclusion: CBD can protect against cardiac injuries, mainly through its antioxidative and antiapoptotic effects
on the basis of non-clinical studies. The cardioprotective effects of the CBD need to be further studied in welldesigned