Hyperferritinaemia: An Iron Sword of Autoimmunity

Author(s): Joanna Giemza-Stokłosa, Md. Asiful Islam, Przemysław J. Kotyla*.

Journal Name: Current Pharmaceutical Design

Volume 25 , Issue 27 , 2019

Abstract:

Background: Ferritin is a molecule that plays many roles being the storage for iron, signalling molecule, and modulator of the immune response.

Methods: Different electronic databases were searched in a non-systematic way to find out the literature of interest.

Results: The level of ferritin rises in many inflammatory conditions including autoimmune disorders. However, in four inflammatory diseases (i.e., adult-onset Still’s diseases, macrophage activation syndrome, catastrophic antiphospholipid syndrome, and sepsis), high levels of ferritin are observed suggesting it as a remarkable biomarker and pathological involvement in these diseases. Acting as an acute phase reactant, ferritin is also involved in the cytokine-associated modulator of the immune response as well as a regulator of cytokine synthesis and release which are responsible for the inflammatory storm.

Conclusion: This review article presents updated information on the role of ferritin in inflammatory and autoimmune diseases with an emphasis on hyperferritinaemic syndrome.

Keywords: Hyperferritinaemia, hyperferritinaemic syndrome, autoimmunity, autoimmune disease, catastrophic antiphospholipid syndrome, macrophage activation syndrome, sepsis, adult-onset Still's disease.

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VOLUME: 25
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Year: 2019
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DOI: 10.2174/1381612825666190709202804
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