Background: Benign prostatic hyperplasia (BPH) and prostate cancer (PCa)
are the most prevalent diseases in male population, implicated with fundamental
differences between benign and malignant growth of prostate cells. An imbalance
through a network of nervous, endocrine, and immune systems initiate a signal of
altered growth from the brain to the prostate gland, leading to adverse effects such as
Objective: The aim of this study was to evaluate the gene expression of dopamine
receptor family, COMT, and IL6 to identify novel correlations in BPH and PCa in both
blood and tumor of the patients.
Methods: Peripheral blood mononuclear cells from BPH (n= 30) and PCa (n= 30)
patients, and prostate tumor tissues (n= 14) along with pathologically normal adjacent
tissues (n= 14) were isolated, mRNA was extracted, and cDNA was synthesized,
respectively. Quantitative real- time PCR was applied for DRD1- DRD5, COMT, and IL6
genes in all samples.
Results: We found, for the first time, that the expression of COMT and IL6 genes were
inversely correlated with the expression of DRD1 and DRD2 genes through the extent of
differentiation of PCa from BPH condition. In addition, the PSA levels were correlated
with the expression of DRD1 in BPH cases and DRD1, DRD4, DRD5, and IL6 in PCa
Conclusion: Results implicate a potential cross- talk between the signaling pathways
derived by IL6 cytokine and dopamine receptors in PCa. Thus, it seems promising to reassemble
the consequent signaling pathways by adequate agonists and antagonists to
help increase therapeutic efficacy.