Diabetes Mellitus (DM) is now a well-known factor which initiates many metabolic derangements in
various tissues and organs including liver, muscle, pancreas, adipose tissue, cardiovascular and nervous system.
Cardiovascular complications are the most crucial , and their effects are so intensive that their derangement leads
to cardiac failure even in the absence of ischemic heart diseases. This entity of cardiac pathology in DM is often
regarded as diabetic cardiomyopathy (DCM). Recently, many plant-derived drugs have been tested to control and
alleviate DCM. Wogonin is one of the drugs the characteristics of which have been deeply studied. Wogonin is a
flavonoid having yellow color pigment in their leaves and is obtained from the roots of plant Scutellaria Baicalensis
Georgi. Wogonin has long been used as an active anti-cancer drug in Chinese medicine practice. In recent
past wogonin has shown to possess notable anti-inflammatory, and anti-allergic properties. Wogonin has
demonstrated to possess anti-oxidant, anti-viral, anti-inflammatory and also anti-thrombotic properties.
Wogonin has shown to alleviate apoptosis, and ER stress in the cells and this property can also be used in the
treatment of cardiovascular diseases. Notably, wogonin has been documented to have an extensive margin of
safety as well as displays little or no organ toxicity following extended intravenous administration. In this review,
we discuss recently discovered therapeutic potential of wogonin in the treatment of DCM.