Parasite infections modulate immunologic responses, and the loss of parasite infections in the
last two to three decades might explain the increased prevalence of allergic diseases in developed countries.
However, parasites can enhance allergic responses. Parasites contain or release allergen-like molecules
that induce the specific immunoglobulin, IgE, and trigger type-2 immune responses. Some parasites
and their proteins, such as Anisakis and Echinococcus granulosus allergens, act as typical allergens.
A number of IgE-binding proteins of various helminthic parasites are cross-reactive to other environmental
allergens, which cause allergic symptoms or hamper accurate diagnosis of allergic diseases. The
cross-reactivity is based on the fact that parasite proteins are structurally homologous to common environmental
allergens. In addition, IgE-binding proteins of parasites might be useful for developing vaccines
to prevent host re-infection. This review discusses the functions of the IgE-biding proteins of parasites.
Keywords: Allergen, Anisakis, Echinococcus granulosus, IgE-binding protein, parasite, helminths.
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