Circulating and Tissue microRNAs as Biomarkers for Ovarian Cancer Prognosis

(E-pub Ahead of Print)

Author(s): Seyed Mostafa Parizadeh*, Reza Jafarzadeh-Esfehani*, Maryam Ghandehari, Malihe Hasanzadeh, Seyed Mohammad Reza Parizadeh, Seyed Mahdi Hassanian, Afsaneh Rezaei-Kalat, Amirsaeed Sabeti Aghabozorgi, Rana Rahimi-Kakhki, Bita Zargaran, Gordon A Ferns, Amir Avan.

Journal Name: Current Drug Targets

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Abstract:

Ovarian cancer (OC) is one of the most common cancers globally with a high rate of cancer-associated mortality. OC may be classified into epithelial cell neoplasms, germ cell neoplasms and stromal cell neoplasms. The five-year survival in the early and advanced stages of disease is approximately 90% and 15%, respectively. microRNAs are short, single-stranded, non-coding ribonucleic acid (RNA). miRNAs play critical roles in post transcriptionally regulations of gene expression. miRNAs are found in different tissues and body fluids. In carcinogenesis the expression of miRNAs are altered. Recent studies have revealed that there is a relationship between alteration of miRNAs expression and the prognosis of patients with OC. The aim of this review was to summarize the findings of recent studies that have investigated the expression of circulating and tissue miRNAs as novel biomarkers in the prognosis of OC.

Keywords: microRNA, ovarian cancer, biomarker, prognosis, tissue, circulating

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/1389450120666190708100308
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