Drug Target Group Prediction with Multiple Drug Networks

(E-pub Ahead of Print)

Author(s): Jingang Che, Lei Chen*, Zi-Han Guo, Shuaiqun Wang, Aorigele.

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

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Background: Identification of drug-target interaction is essential in drug discovery. It is beneficial to predict unexpected therapeutic or adverse side effects of drugs. To date, several computational methods have been proposed to predict drug-target interactions because they were quick and low cost compared with traditional wet experiments.

Methods: In this study, we investigated this problem in a different way. According to KEGG, drugs were classified into several groups based on their target proteins. A multi-label classification model was presented to assign drugs into correct target groups. To make full use of known drug properties, five networks were constructed, each of which represented drug associations in one property. A powerful network embedding method, Mashup, was adopted to extract drug features from above-mentioned networks, based on which several machine learning algorithms, including RAndom k-labELsets (RAKEL) algorithm, Label Powerset (LP) algorithm and support vector machine (SVM), were used to build the classification model.

Results and Conclusion: Tenfold cross-validation yielded the accuracy of 0.839, exact match of 0.816 and hamming loss of 0.037, indicating the good performance of the model. The contribution of each network was also analyzed. Furthermore, the network model with multiple networks was superior to that with certain single network and classic model, indicating the superiority of the proposed model.

Keywords: drug-target interaction, drug target group, multiple drug networks, Meka, Mulan, support vector machine

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(E-pub Ahead of Print)
DOI: 10.2174/1386207322666190702103927
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