Background: Synthesis of acridinedione derivatives via one-pot multi-component approaches
using highly active and reusable Pd/AlO(OH) heterogenous catalyst was studied. This process
provided a convenient method to obtain various acridinediones with potential biological activities.
The reactions were performed in mild conditions such as low temperature and short reaction
time with desirable yields.
Methods: Commercially available Pd/AlO(OH) nanoparticles characterized by XRD and SEM methods
were afforded for the synthesis of acridinedione derivatives with high yields. Crude products
were analyzed by GC and 1H NMR. The reactions were completed within 1h at 40°C by the assistance
of ultrasound system.
Results: Optimization of reaction conditions is of critical case for successful synthesis. Solvent, temperature,
time and amount of catalyst were studied. At the end of the experiments, the synthesis of 1
mmol of acridinedione was optimized by using 25 mg of Pd/AlO(OH) NPs, 3 ml of DMF for 60 min
at 40°C in the ultrasound system. An experimental work to check the reusability of the catalyst was
also studied. Pd/Al(O)OH catalyst in the first run was higher than that of the reused catalyst in the
fifth run. ICP-OES analyses showed palladium leaching into the reaction medium was only 1.1%
which is negligible. Nanocatalyst employed a high activity and good reusability.
Conclusion: A convenient and versatile method was developed for the synthesis of acridinediones in
a mild condition with absolute conversion and high yield using ultrasound system in the presence of