Positive Association Between Plasma Levels of Advanced Glycation and Precursor of Lipoxidation end Products with Gastrointestinal Problems in Children with Autism

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Author(s): Ramin Ghodsi, Sorayya Kheirouri*.

Journal Name: Current Pediatric Reviews

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Background: Increased oxidative stress has been reported in autistic patients. Besides, evidence linking oxidative stress to enhancement of advanced glycation and lipoxidation end products (AGEs and ALEs) and their precursors.

Objective: This study was aimed to compare the plasma levels of the AGEs and precursors of ALEs in autistic and healthy children and to evaluate their relation with autism comorbidities.

Methods: In this cross-sectional study, 54 children, 36 autistic and 18 healthy, participated. Plasma levels of AGEs and precursors of ALEs were measured by ELISA method. Severity of autism and GI disorders were measured by GARSII questionnaire and QPGS-ROMEIII questionnaire, respectively.

Results: Plasma levels of AGEs and precursors of ALEs in autistic children was comparable with healthy children. Plasma levels of AGEs and precursor of ALEs were correlated with physical activity and GI disorders in autistic children. A strong association was also found between AGEs and precursors of ALEs.

Conclusions: The results indicated that AGEs and ALEs have a strong correlation together but the AGEs and precursor of ALEs in autistic children are not different from healthy children.

Keywords: Autism spectrum disorders, Advanced glycation end products, Advanced lipoxidation end products, Methylglyoxal, Malondialdehyde, Lipid peroxidation

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(E-pub Ahead of Print)
DOI: 10.2174/1573396315666190628141333